The Bufo alvarius toad, also known as the Colorado River toad or Sonoran Desert toad, is known for its ability to produce psychoactive effects in humans when its venom is ingested or smoked.
The main psychoactive compound found in the venom of this toad is 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), which is a powerful hallucinogenic substance. The process by which the Bufo alvarius toad induces psychedelic experiences in people involves the interaction between the 5-MeO-DMT (DMT) compound and the human brain.
The Bufo alvarius toad is found in the wild in parts of Arizona, New Mexico, Texas, and northern Mexico, specifically in the states of Sonora and Chihuahua. These toads are typically found in deserts and semi-deserts, and they inhabit areas with sandy or rocky soils and sparse vegetation. The toad is thought to have migrated to the southwestern United States and northern Mexico through the Rio Grande River, with evidence of their existence in the region dating as far back as 10,000 years ago.
When the venom of the Bufo alvarius toad is collected and dried, it can be smoked or vaporized, allowing the DMT to be inhaled.
Once inhaled, the compound rapidly crosses the blood-brain barrier and binds to serotonin receptors in the brain. Specifically, it has a high affinity for the 5-HT2A receptor subtype, which is known to play a key role in mediating psychedelic experiences. The binding of DMT to these receptors leads to a cascade of neurochemical events that ultimately result in altered perception, cognition, and consciousness. Or in other words: tripping balls.
The exact mechanisms through which this occurs are still not fully understood. One hypothesis suggests that the activation of 5-HT2A receptors by 5-MeO-DMT leads to an increase in cortical excitability, causing a breakdown of normal sensory processing and integration. This breakdown allows for the emergence of novel patterns of perception and cognition, leading to hallucinations, and altered sense of self. One of the greatest heavyweight boxing champions of all time Mike Tyson famously said on the Joe Rogan Experience podcast that he had once tried the toad and has never been the same since. DMT has been shown to increase the release of neurotransmitters such as dopamine and serotonin, which are involved in mood regulation and the reward system. This may contribute to the intense emotional experiences including feelings of euphoria, awe, and connection with the universe or higher power.
It is important to note that the effects of Bufo alvarius toad venom can vary widely among individuals, and the intensity and nature of the psychedelic experience can be influenced by factors such as dosage, mental state, setting, and individual susceptibility. Additionally, the use of the toad carries potential risks and should be approached with caution. It is advisable to seek guidance from experienced practitioners or researchers who can provide a safe and supportive environment for its use.
In conclusion, the toad sounds a little bit too intense for my liking, but also appears to be harmless and a potentially beneficial experience for some.
